响应面法优化植物软胶囊囊皮制备工艺

李佳, 陈皓玉, 张文慧, 张林波

中国药学杂志 ›› 2019, Vol. 54 ›› Issue (11) : 894-899.

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中国药学杂志 ›› 2019, Vol. 54 ›› Issue (11) : 894-899. DOI: 10.11669/cpj.2019.11.007
论著

响应面法优化植物软胶囊囊皮制备工艺

  • 李佳, 陈皓玉, 张文慧, 张林波*
作者信息 +

Process Optimization for Preparation Plant-derived Soft Capsule Shell by Response Surface Analysis

  • LI Jia, CHEN Hao-yu, ZHANG Wen-hui, ZHANG Lin-bo*
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文章历史 +

摘要

目的 以卡拉胶、变性淀粉为主要原料,结合辅料制备植物软胶囊囊皮并进行性能测试。方法 采用D-最优混料设计,通过改变各因素的质量制备植物软胶囊囊皮,使用响应面法对囊皮进行力学性能和水蒸气透过系数分析,并优化囊皮的最适配方。结果 甘油与水保持一定量时,当κ-卡拉胶0.9 g,ι-卡拉胶10.5 g,氧化淀粉1.636 g,热处理淀粉16.964 g时,由此制得囊皮的抗拉强度达到最大,杨氏模量、水蒸气透过系数达到最小,囊皮的性能最优。结论 本实验为植物软胶囊代替动物明胶软胶囊奠定理论基础。

Abstract

OBJECTIVE To develop plant-derived soft capsule shell with carrageenan, modified starch and investigate their properties. METHODS The plant-derived soft capsule shell was prepared by using D-optimal mixture design and changing the quality of each factor. The mechanical properties and water vapor permeability coefficient of capsule skin were analyzed by response surface methodology, and the optimum formulation of capsule shell was optimized. RESULTS When glycerol and water remain constant, under the optimized conditions, edible capsule shell consisting of κ-carrageenan 0.9 g, ι-carrageenan 10.5 g, oxidized starch 1.636 g and heat-treated starch 16.964 g showed the best properties of tensile strength, Young′s modulus and water vapor permeability. CONCLUSION This study lays theoretical foundation for replacing gelatin soft capsules with plant-derived soft capsules.

关键词

植物软胶囊 / 抗拉强度 / 杨氏模量 / 水蒸气透过系数 / 响应面分析

Key words

plant-derived soft capsule / tensile strength / Young′s modulus / water vapor permeability / response surface analysis

引用本文

导出引用
李佳, 陈皓玉, 张文慧, 张林波. 响应面法优化植物软胶囊囊皮制备工艺[J]. 中国药学杂志, 2019, 54(11): 894-899 https://doi.org/10.11669/cpj.2019.11.007
LI Jia, CHEN Hao-yu, ZHANG Wen-hui, ZHANG Lin-bo. Process Optimization for Preparation Plant-derived Soft Capsule Shell by Response Surface Analysis[J]. Chinese Pharmaceutical Journal, 2019, 54(11): 894-899 https://doi.org/10.11669/cpj.2019.11.007
中图分类号: R944   

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基金

吉林省教育厅“十三·五”科学技术项目资助(JJKH20170304KJ)

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